Prostaceutix contains 30 handpicked ingredients that have the power to reset the 9 fundamental biochemical pathways involved in an enlarged prostate.

This unique and exclusive formulation is called “Metabolic Pathway Resetting Formula.” 

It is the name of the exclusive formula behind Prostaceutix. All the ingredients are formulated to target the 9 fundamental biochemical pathways involved in Benign Prostate Hyperplasia (the clinical name for an enlarged prostate).

The big difference is the “Metabolic Pathway Resetting Formula” which is an exclusive formula that targets the 9 fundamental biochemical pathways involved in an enlarged prostate.

No other nutraceutical has this unique formula.

Since Prostaceutix is a natural product made with organic ingredients, the likelihood of experiencing side effects is close to zero. Obviously, you must follow the instructions on the bottle.

FDA doesn’t approve nutraceuticals but registers facilities to ensure the quality of the supplements. Prostaceutix is manufactured in an FDA registered facility. It respects the “good manufacturing practice” standards.

Prostaceutix is manufactured exclusively for Men’z Care solutions.

It is made with natural and organic ingredients only. Prostaceutix is assembled utilizing the latest scientific research and formulated only with high-quality ingredients.

Each batch is tested by a third-party independent laboratory to ensure that each capsule contains what’s written on the label and that there are no heavy metal impurities.
 Prostaceutix is manufactured in a facility that is GMP (Good Manufacturing Practice) certified, and FDA registered.

Conclusion, only 1% of the supplement on the market can match our world-class standards.

Even though Prostaceutix is a powerful nutraceutical, it is still a natural product. It does not have the chemical power of medications that can induce changes rapidly but have many side effects.
 
So, for you to see changes it may take a few weeks in that majority of cases, but it can go as far as few months. Not all bodies react the same to a product.

Be patient, the formula works.

In general, symptoms from a growing prostate start slowly.
 
At first, it can be noticed as:

o A weaker stream
o Getting up 2-3 times per night
o Feeling that there is always something in your bladder.

As time passes, the stream gets weaker, you get up more often at night and you can’t empty your bladder in one stream, you pee intermittently, and you dribble in your underwear.

As the problem worsens, you have urgency night and day, your libido decreases, and you might have a problem having a solid erection.

As the prostate grows, the pressure upon your urethra (the tube in your penis that connects to your bladder) is increased to a point that it can completely block the flow of urine. At this point, you might need surgery. During this intervention, a tool is inserted in your penis to reach the prostate and then the compressing part is removed.

 Also, if the urine stagnates in your bladder, it can cause infection that can reach your kidneys. This situation is serious and even life-threatening.

Among the other important complication, is the fact that a swollen prostate can lead to erectile dysfunction

We see that you have done your homework.

It is right that some studies say that Saw Palmetto is no better than a placebo. However, if you dig into those research, you find that saw palmetto was studied alone, with no other ingredients that are known to potentialize its effect.

Also, sometimes, the quantity of saw palmetto given to the patients was not high enough to ensure a physiological effect.

 Prostaceutix, contains ingredients that are known to potentialize each other, and on top of that, the Biosynergetic Proprietary Blend had been developed to optimize the synergy, the potency, and the intensity of the Metabolic Pathway Resetting Formula.

There are 2 main reasons you might experience a low libido if you suffer from an enlarged prostate.

 The first is psychological. As the symptoms directly related to your swollen prostate increase, many men feel they are losing their “manhood” and their “male confidence” drops.
 
The second reason is pharmaceutical. Many of the medications prescribed for an enlarged prostate have as a side effect, a decrease libido.

 By using Prostaceutix, as your prostate problems fade away, your doctor might reduce or even stop your medication. This can contribute to increasing your libido.

Lorem ipsum dolor sit amet, consectetur adipisicing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur.

1. Salinas-Casado, J., Esteban-Fuertes, M., Carballido-Rodríguez, J., & Cozar-Olmo, J. M. (2020). Review of the experience and evidence of Pygeum africanum in urological practice. Revisión sobre la experiencia y evidencias del Pygeum africanum en Urología.Actas urologicas espanolas,44(1), 9–13. https://doi.org/10.1016/j.acuro.2019.08.002

2. Lim, S. H., & Choi, C. I. (2021). Potentials of Raspberry Ketone as a Natural Antioxidant.Antioxidants (Basel, Switzerland),10(3), 482. https://doi.org/10.3390/antiox10030482

3. Park K. S. (2010). Raspberry ketone increases both lipolysis and fatty acid oxidation in 3T3-L1 adipocytes.Planta medica,76(15), 1654–1658. https://doi.org/10.1055/s-0030-1249860

4. Rothenberg, D. O., Zhou, C., & Zhang, L. (2018). A Review on the Weight-Loss Effects of Oxidized Tea Polyphenols.Molecules (Basel, Switzerland),23(5), 1176. https://doi.org/10.3390/molecules23051176

5. Bogdanski, P., Suliburska, J., Szulinska, M., Stepien, M., Pupek-Musialik, D., & Jablecka, A. (2012). Green tea extract reduces blood pressure, inflammatory biomarkers, and oxidative stress and improves parameters associated with insulin resistance in obese, hypertensive patients.Nutrition research (New York, N.Y.),32(6), 421–427. https://doi.org/10.1016/j.nutres.2012.05.007

6. Haidari, F., Samadi, M., Mohammadshahi, M., Jalali, M. T., & Engali, K. A. (2017). Energy restriction combined with green coffee bean extract affects serum adipocytokines and the body composition in obese women.Asia Pacific journal of clinical nutrition,26(6), 1048–1054. https://doi.org/10.6133/apjcn.022017.03

7. Ueland, P. M., McCann, A., Midttun, Ø., & Ulvik, A. (2017). Inflammation, vitamin B6 and related pathways.Molecular aspects of medicine,53, 10–27 https://doi.org/10.1016/j.mam.2016.08.001

8. Bird R. P. (2018). The Emerging Role of Vitamin B6 in Inflammation and Carcinogenesis.Advances in food and nutrition research,83, 151–194. https://doi.org/10.1016/bs.afnr.2017.11.004

9. Mascolo, E., & Vernì, F. (2020). Vitamin B6 and Diabetes: Relationship and Molecular Mechanisms.International journal of molecular sciences,21(10), 3669. https://doi.org/10.3390/ijms21103669

10. Chilelli, N. C., Ragazzi, E., Valentini, R., Cosma, C., Ferraresso, S., Lapolla, A., & Sartore, G. (2016). Curcumin and Boswellia serrata Modulate the Glyco-Oxidative Status and Lipo-Oxidation in Master Athletes. Nutrients, 8(11), 745. https://doi.org/10.3390/nu8110745

11. Barzegar, A., & Moosavi-Movahedi, A. A. (2011). Intracellular ROS protection efficiency and free radical-scavenging activity of curcumin. PloS one, 6(10), e26012. https://doi.org/10.1371/journal.pone.0026012

12. Banik, U., Parasuraman, S., Adhikary, A. K., & Othman, N. H. (2017). Curcumin: the spicy modulator of breast carcinogenesis. Journal of experimental & clinical cancer research : CR, 36(1), 98. https://doi.org/10.1186/s13046-017-0566-5

13. Suhett, L. G., de Miranda Monteiro Santos, R., Silveira, B., Leal, A., de Brito, A., de Novaes, J. F., & Lucia, C. (2021). Effects of curcumin supplementation on sport and physical exercise: a systematic review. Critical reviews in food science and nutrition, 61(6), 946–958. https://doi.org/10.1080/10408398.2020.1749025

14. Pivari, F., Mingione, A., Brasacchio, C., & Soldati, L. (2019). Curcumin and Type 2 Diabetes Mellitus: Prevention and Treatment. Nutrients, 11(8), 1837.https://doi.org/10.3390/nu11081837

15. Ashtary-Larky, D., Rezaei Kelishadi, M., Bagheri, R., Moosavian, S. P., Wong, A., Davoodi, S. H., Khalili, P., Dutheil, F., Suzuki, K., & Asbaghi, O. (2021). The Effects of Nano-Curcumin Supplementation onRisk Factors for Cardiovascular Disease: A GRADE-Assessed Systematic Review and Meta-Analysis of Clinical Trials. Antioxidants (Basel, Switzerland), 10(7), 1015.https://doi.org/10.3390/antiox10071015

16. Evron, E., Juhasz, M., Babadjouni, A., & Mesinkovska, N. A. (2020). Natural Hair Supplement: Friend or Foe? Saw Palmetto, a Systematic Review in Alopecia. Skin appendage disorders, 6(6), 329–337. https://doi.org/10.1159/000509905

17. Kwon Y. (2019). Use of saw palmetto (Serenoa repens) extract for benign prostatic hyperplasia. Food science and biotechnology, 28(6), 1599–1606. https://doi.org/10.1007/s10068-019-00605-9

18. Gombart, A. F., Pierre, A., & Maggini, S. (2020). A Review of Micronutrients and the Immune System-Working in Harmony to Reduce the Risk of Infection. Nutrients, 12(1), 236. https://doi.org/10.3390/nu12010236

19. Heffernan, S. M., Horner, K., De Vito, G., & Conway, G. E. (2019). The Role of Mineral and Trace Element Supplementation in Exercise and Athletic Performance: A Systematic Review. Nutrients, 11(3), 696. https://doi.org/10.3390/nu11030696

20. Wang, N., Tan, H. Y., Li, S., Xu, Y., Guo, W., & Feng, Y. (2017). Supplementation of Micronutrient Selenium in Metabolic Diseases: Its Role as an Antioxidant. Oxidative medicine and cellular longevity, 2017, 7478523. https://doi.org/10.1155/2017/7478523

21. Wichman, J., Winther, K. H., Bonnema, S. J., & Hegedüs, L. (2016). Selenium Supplementation Significantly Reduces Thyroid Autoantibody Levels in Patients with Chronic Autoimmune Thyroiditis: A Systematic Review and Meta-Analysis. Thyroid : official journal of the American Thyroid Association, 26(12), 1681–1692. https://doi.org/10.1089/thy.2016.0256

22. Benstoem, C., Goetzenich, A., Kraemer, S., Borosch, S., Manzanares, W., Hardy, G., & Stoppe, C. (2015). Selenium and its supplementation in cardiovascular disease--what do we know?. Nutrients, 7(5), 3094–3118. https://doi.org/10.3390/nu7053094

23. Maywald, M., Wessels, I., & Rink, L. (2017). Zinc Signals and Immunity. International journal of molecular sciences, 18(10), 2222. https://doi.org/10.3390/ijms18102222

24. Wessels, I., Rolles, B., & Rink, L. (2020). The Potential Impact of Zinc Supplementation on COVID-19 Pathogenesis. Frontiers in immunology, 11, 1712. https://doi.org/10.3389/fimmu.2020.01712

25. Vahlensieck, W., Theurer, C., Pfitzer, E., Patz, B., Banik, N., & Engelmann, U. (2015). Effects of pumpkin seed in men with lower urinary tract symptoms due to benign prostatic hyperplasia in the one-year, randomized, placebo-controlled GRANU study. Urologia internationalis, 94(3), 286–295. https://doi.org/10.1159/000362903

26. Hsu, Y. J., Huang, W. C., Chiu, C. C., Liu, Y. L., Chiu, W. C., Chiu, C. H., Chiu, Y. S., & Huang, C. C. (2016). Capsaicin Supplementation Reduces Physical Fatigue and Improves Exercise Performance in Mice. Nutrients, 8(10), 648. https://doi.org/10.3390/nu8100648

27. Eichner E. R. (2016). Fighting Muscle Cramps With Two Spices and One Hot Fruit. Current sports medicine reports, 15(5), 304–305. https://doi.org/10.1249/JSR.0000000000000298

28. Ziaei R, Foshati S, Hadi A, Kermani MAH, Ghavami A, Clark CCT, Tarrahi MJ. The effect of nettle (Urtica dioica) supplementation on the glycemic control of patients with type 2 diabetes mellitus: A systematic review and meta-analysis. Phytother Res. 2020 Feb;34(2):282-294. doi: 10.1002/ptr.6535. Epub 2019 Dec 4. PMID: 31802554.

29. Chen, P., Zhang, W., Wang, X., Zhao, K., Negi, D. S., Zhuo, L., Qi, M., Wang, X., & Zhang, X. (2015). Lycopene and Risk of Prostate Cancer: A Systematic Review and Meta-Analysis. Medicine, 94(33), e1260. https://doi.org/10.1097/MD.0000000000001260

30. Beynon, R. A., Richmond, R. C., Santos Ferreira, D. L., Ness, A. R., May, M., Smith, G. D., Vincent, E. E., Adams, C., Ala-Korpela, M., Würtz, P., Soidinsalo, S., Metcalfe, C., Donovan, J. L., Lane, A. J., Martin, R. M., ProtecT Study Group, & PRACTICAL consortium (2019). Investigating the effects of lycopene and green tea on the metabolome of men at risk of prostate cancer: The ProDiet randomised controlled trial. International journal of cancer, 144(8), 1918–1928. https://doi.org/10.1002/ijc.31929

31. Shanbhag V. K. (2016). Lycopene in cancer therapy. Journal of pharmacy & bioallied sciences, 8(2), 170–171. https://doi.org/10.4103/0975-7406.171740

32. Hetland G, Tangen JM, Mahmood F, Mirlashari MR, Nissen-Meyer LSH, Nentwich I, Therkelsen SP, Tjønnfjord GE, Johnson E. Antitumor, Anti-Inflammatory and Antiallergic Effects of Agaricus blazeiMushroom Extract and the Related Medicinal Basidiomycetes Mushrooms, Hericium erinaceusand Grifolafrondosa: A Review of Preclinical and Clinical Studies. Nutrients. 2020 May 8;12(5):1339. doi: 10.3390/nu12051339. PMID: 32397163; PMCID: PMC7285126.

33. Mallard B, Leach DN, Wohlmuth H, Tiralongo J. Synergistic immuno-modulatory activity in human macrophages of a medicinal mushroom formulation consisting of Reishi, Shiitake and Maitake. PLoS One. 2019 Nov 7;14(11):e0224740. doi: 10.1371/journal.pone.0224740. PMID: 31697749; PMCID: PMC6837746.

34. Afshar K, Fleischmann N, Schmiemann G, Bleidorn J, Hummers-Pradier E, Friede T, Wegscheider K, Moore M, Gágyor I. Reducing antibiotic use for uncomplicated urinary tract infection in general practice by treatment with uva-ursi (REGATTA) -a double-blind, randomized, controlled comparative effectiveness trial. BMC Complement Altern Med. 2018 Jul 3;18(1):203. doi: 10.1186/s12906-018-2266-x. PMID: 29970072; PMCID: PMC6029138 

35. Dandare SU, Ezeonwumelu IJ, Shinkafi TS, Magaji UF, Adio AA, Ahmad K. L-alanine supplementation improves blood glucose level and biochemicalindices in alloxan-induced diabetic rats. J Food Biochem. 2021 Jan;45(1):e13590. doi: 10.1111/jfbc.13590. Epub 2020 Dec 21. PMID: 33346923.

36. Sekhar, R. V., Patel, S. G., Guthikonda, A. P., Reid, M., Balasubramanyam, A., Taffet, G. E., & Jahoor, F. (2011). Deficient synthesis of glutathione underlies oxidative stress in aging and can be corrected by dietary cysteine and glycine supplementation. The American journal of clinical nutrition, 94(3), 847–853. https://doi.org/10.3945/ajcn.110.003483

37. Razak, M. A., Begum, P. S., Viswanath, B., & Rajagopal, S. (2017). Multifarious Beneficial Effect of Nonessential Amino Acid, Glycine: A Review. Oxidative medicine and cellular longevity, 2017, 1716701. https://doi.org/10.1155/2017/1716701

38. Bonaterra GA, Bronischewski K, Hunold P, Schwarzbach H, Heinrich EU, Fink C, Aziz-Kalbhenn H, Müller J, Kinscherf R. Anti-inflammatory and Anti-oxidative Effects of Phytohustil® and Root Extract of Althaea officinalisL. on Macrophages in vitro. Front Pharmacol. 2020 Mar 17;11:290. doi: 10.3389/fphar.2020.00290. PMID: 32256361; PMCID: PMC7090173.

39. Goldenseal. (2021). In Drugs and Lactation Database (LactMed). National Library of Medicine (US).

40. Mandal, S. K., Maji, A. K., Mishra, S. K., Ishfaq, P. M., Devkota, H. P., Silva, A. S., & Das, N. (2020). Goldenseal (Hydrastis canadensis L.) and its active constituents: A critical review of their efficacy and toxicological issues. Pharmacological research, 160, 105085. https://doi.org/10.1016/j.phrs.2020.105085

41. Mara de Menezes Epifanio, N., Rykiel Iglesias Cavalcanti, L., Falcão Dos Santos, K., Soares Coutinho Duarte, P., Kachlicki, P., Ożarowski, M., Jorge Riger, C., & Siqueira de Almeida Chaves, D. (2020). Chemical characterization and in vivo antioxidant activity of parsley (Petroselinum crispum) aqueous extract. Food & function, 11(6), 5346–5356. https://doi.org/10.1039/d0fo00484g

42. Jovic, T. H., Ali, S. R., Ibrahim, N., Jessop, Z. M., Tarassoli, S. P., Dobbs, T. D., Holford, P., Thornton, C. A., & Whitaker, I. S. (2020). Could Vitamins Help in the Fight Against COVID-19?. Nutrients, 12(9), 2550. https://doi.org/10.3390/nu12092550

43. Traber, M. G., & Atkinson, J. (2007). Vitamin E, antioxidant and nothing more. Free radical biology & medicine, 43(1), 4–15. https://doi.org/10.1016/j.freeradbiomed.2007.03.024

44. Wu, D., & Meydani, S. N. (2014). Age-associated changes in immune function: impact of vitamin E intervention and the underlying mechanisms. Endocrine, metabolic & immune disorders drug targets, 14(4), 283–289. https://doi.org/10.2174/1871530314666140922143950

45. De la Fuente, M., Hernanz, A., Guayerbas, N., Victor, V. M., & Arnalich, F. (2008). Vitamin E ingestion improves several immune functions in elderly men and women. Free radical research, 42(3), 272–280. https://doi.org/10.1080/10715760801898838

46. Browne, D., McGuinness, B., Woodside, J. V., & McKay, G. J. (2019). Vitamin E and Alzheimer's disease: what do we know so far?. Clinical interventions in aging, 14, 1303–1317. https://doi.org/10.2147/CIA.S186760

1. Ajayi A., Abrahama K. Understanding the role of estrogen in the development of benign prostatic hyperplasia. African Journal of Urology (2018) 24, 93–97. https://doi.org/10.1016/j.afju.2018.01.005

2. Lusty A, Siemens DR, Tohidi M. Cardiac failure associated with medical therapy of benign prostatic hyperplasia: a population based study. J Urol. Published online February 22, 2021

3. Lobo, v. et al. Free radicals, antioxidants and functional foods: Impact on human health. Pharmacogn Rev. 2010 Jul-Dec; 4(8): 118–126. doi: 10.4103/0973-7847.70902

4. Bostanci Y, Kazzazi A, Momtahen S, Laze J, Djavan B: Correlation between benign prostatic hyperplasia and inflammation. Curr Opin Urol 2013; 23: 5–10.

5. Minciullo, P.L. and al. Oxidative Stress in Benign Prostatic Hyperplasia: A Systematic Review. Urol Int 2015;94:249–254, DOI: 10.1159/000366210

6. Furman D. et al. Chronic inflammation in the etiology of disease across the life span. Nature Medicine, Vol 25, December 2019, 1822–1832. https://doi.org/10.1038/s41591-019-0675-0

7. Kim WT, et al. Association between Prostate Size and Fasting Glucose Level. J Korean Med Sci 2011; 26: 1214-1218. http://dx.doi.org/10.3346/jkms.2011.26.9.1214

8. Rył et al. Metabolic syndrome and benign prostatic hyperplasia: association or coincidence? Diabetol Metab Syndr (2015) 7:94. DOI 10.1186/s13098-015-0089-1

9. Zhou B. et al. Correlations of glucose metabolism, insulin resistance and inflammatory factors with symptom score of patients with benign prostatic hyperplasia. European Review for Medical and Pharmacological Sciences, 2018; 22: 5077-5081

10. Vikram, A., Jena, G., Ramarao, P., 2010b. Pioglitazone attenuates prostatic enlargement in diet-induced insulin-resistant rats by altering lipid distribution and hyperinsulinaemia. Brit J Pharmacol, 161, 1708-1721.

11. Vikram, A., Jena, G., Ramarao, P., 2011a. Insulin-resistance reduces botulinum neurotoxintype A induced prostatic atrophy and apoptosis in rats. Eur J Pharmacol, 650, 356-363.

12. Vikram, A., Jena, G.B., Ramarao, P., 2010c. Increased cell proliferation and contractility of prostate in insulin resistant rats: linking hyperinsulinemia with benign prostate hyperplasia. Prostate, 70, 79-89.

13. Cai, X., Haleem, R., Oram, S., Cyriac, J., Jiang, F., Grayhack, J.T., Kozlowski, J.M., Wang, Z., 2001. High fat diet increases the weight of rat ventral prostate. Prostate, 49, 1-8.

14. Moyad, M.A., Lowe, F.C., 2008. Educating patients about lifestyle modifications for prostate health. Am J Med, 121, S34-42.

15. Lambert MA et al. Prevalence and Distribution of Atherosclerosis in a Low- to Intermediate-Risk Population: Assessment with Whole-Body MR Angiography. Radiology: Volume 287: Number 3—June 2018. https://doi.org/10.1148/radiol.2018171609


16. Berger AP et al. Atherosclerosis as a risk factor for benign prostatic hyperplasia. BJU International, Volume 98, Issue 5. November 2006, Pages 1038-1042. https://doi.org/10.1111/j.1464-410X.2006.06400.x 

17. https://ag.ny.gov/press-release/2015/ag-schneiderman-asks-major-retailers-halt-sales-certain-herbal-supplements-dna 

18. Rachael Rettner, Hundreds of Dietary Supplements Are Tainted with Prescription Drugs. Scientific American, October 12, 2018. https://www.scientificamerican.com/article/hundreds-of-dietary-supplements-are-tainted-with-prescription-drugs/  

19. Sokeland J, Albrecht J. Combination of Sabal and Urtica extract vs. finasteride in benign prostatic hyperplasia (Aiken stages I to II). Comparison of therapeutic effectiveness in a one year double-blind study. Urology 1997;36(4):327-33. 

20. Hartmann RW, Mark M, Soldati F. Inhibition of 5-a-reductase and aromatase by PHL-00801 a combination of PY102 (Pygeum africanum) and UR102 (Urtica dioica) extracts. Phytomedicine 1996; 3(2):121-128.

21. Ye Z. et al. Efficacy and Safety of Serenoa repens Extract Among Patients with Benign Prostatic Hyperplasia in China: A Multicenter, Randomized, Double-blind, Placebo-controlled Trial. Urology. 2019 Jul;129:172-179. DOI: 10.1016/j.urology.2019.02.030

22. Larré S. et al. Biological effect of human serum collected before and after oral intake of Pygeum africanum on various benign prostate cell cultures. Asian J Androl. 2012 May; 14(3): 499–504. doi: 10.1038/aja.2011.132

23. Carani C. et al. Urological and sexual evaluation of treatment of benign prostatic disease using Pygeum africanum at high doses. Arch Ital Urol Nefrol Androl. 1991 Sep;63(3):341-5. 

24. RoyUpton, R.H. DAyu. Stinging nettles leaf (Urtica dioica L.): Extraordinary vegetable medicine. Journal of Herbal Medicine, Volume 3, Issue 1, March 2013, Pages 9-38

25. A Nahata , V K Dixit. Ameliorative effects of stinging nettle (Urtica dioica) on testosterone-induced prostatic hyperplasia in rats. Andrologia. 2012 May;44 Suppl 1:396-409. doi: 10.1111/j.1439-0272.2011.01197.x.

26. Leonard S Marks. 5alpha-reductase: history and clinical importance. Rev Urol. 2004;6 Suppl 9(Suppl 9):S11-21.

27. Jacquet A. et al. Phytalgic, a food supplement, vs placebo in patients with osteoarthritis of the knee or hip: a randomised double-blind placebo-controlled clinical trial. Arthritis Res Ther. 2009;11(6):R192. doi: 10.1186/ar2891.

28. Kianbakht S. et al. Improved glycemic control in patients with advanced type 2 diabetes mellitus taking Urtica dioica leaf extract: a randomized double-blind placebo-controlled clinical trial. Clin Lab. 2013;59(9-10):1071-6. doi: 10.7754/clin.lab.2012.121019.

29. Gohari A. et al. Urtica Dioica Distillate Regenerates Pancreatic Beta Cells in Streptozotocin-Induced Diabetic Rats. Iran J Med Sci. 2018 Mar;43(2):174-183.

30. Obanda D.N. et al. An extract of Urtica dioica L. mitigates obesity induced insulin resistance in mice skeletal muscle via protein phosphatase 2A (PP2A). Sci Rep. 2016 Feb 26;6:22222. doi: 10.1038/srep22222.

31. Said O. et al. Maintaining a physiological blood glucose level with 'glucolevel', a combination of four anti-diabetes plants used in the traditional arab herbal medicine. Evid Based Complement Alternat Med. 2008 Dec;5(4):421-8. doi: 10.1093/ecam/nem047. 

32. Kianbakht S. et al. Improved glycemic control in patients with advanced type 2 diabetes mellitus taking Urtica dioica leaf extract: a randomized double-blind placebo-controlled clinical trial. Clin Lab. 2013;59(9-10):1071-6. doi: 10.7754/clin.lab.2012.121019.


33. Masoud Shabani Domola et al. Insulin mimetics in Urtica dioica: structural and computational analyses of Urtica dioica extracts. Phytother Res. 2010 Jun;24 Suppl 2:S175-82. doi: 10.1002/ptr.3062.

34. Britt M Burton-Freeman, Amandeep K Sandhu, Indika Edirisinghe. Red Raspberries and Their Bioactive Polyphenols: Cardiometabolic and Neuronal Health Links. Adv Nutr. 2016 Jan 15;7(1):44-65. doi: 10.3945/an.115.009639.

35. Britt M Burton-Freeman, Amandeep K Sandhu, Indika Edirisinghe. Red Raspberries and Their Bioactive Polyphenols: Cardiometabolic and Neuronal Health Links. Adv Nutr. 2016 Jan 15;7(1):44-65. doi: 10.3945/an.115.009639.

36. Chacko SM. and al. Beneficial effects of green tea: A literature review. Chin Med. 2010; 5: 13. doi: 10.1186/1749-8546-5-13

37. Nehlig A and al. Caffeine and the central nervous system: mechanisms of action, biochemical, metabolic and psychostimulant effects. in Res Rev. May-Aug 1992;17(2):139-70. doi: 10.1016/0165-0173(92)90012-b.

38. Ruxton C.H.S. et al. The impact of caffeine on mood, cognitive function, performance and hydration: a review of benefits and risks. Nutrition Bulletin, Volume33, Issue1. March 2008. https://doi. org/10.1111/j.1467-3010.2007.00665.x

39. Weinreb O. et al. Neurological mechanisms of green tea polyphenols in Alzheimer's and Parkinson's diseases. utr Biochem. 2004 Sep;15(9):506-16. doi: 10.1016/j.jnutbio.2004.05.002. 

40. https://www.nia.nih.gov/health/what-alzheimers-disease 

41. Kurahashi N. et al. Green Tea Consumption and Prostate Cancer Risk in Japanese Men: A Prospective Study. American Journal of Epidemiology, Volume 167, Issue 1, 1 January 2008, Pages 71–77, https://doi.org/10.1093/aje/kwm249 

42. Chen Y. et al. An inverse association between tea consumption and colorectal cancer risk. Oncotarget. 2017 Jun 6;8(23):37367-37376. doi: 10.18632/oncotarget.16959.

43. Edward Giovannucci. A review of epidemiologic studies of tomatoes, lycopene, and prostate cancer. Exp Biol Med (Maywood). 2002 Nov;227(10):852-9. doi: 10.1177/153537020222701003. 

44. Michaud D S. et al. Intake of specific carotenoids and risk of lung cancer in 2 prospective US cohorts. Am J Clin Nutr. 2000 Oct;72(4):990-7. doi: 10.1093/ajcn/72.4.990. 

45. P Brennan et al. A multicenter case-control study of diet and lung cancer among non-smokers. Cancer Causes Control. 2000 Jan;11(1):49-58. doi: 10.1023/a:1008909519435. 

46. Jacques P.F. et al. Relationship of lycopene intake and consumption of tomato products to incident CVD. Br J Nutr. 2013 Aug 28;110(3):545-51. doi: 10.1017/S0007114512005417. Epub 2013 Jan 15.

47. Xinli Li , Jiuhong Xu. Dietary and circulating lycopene and stroke risk: a meta-analysis of prospective studies. Rep. 2014 May 22;4:5031. doi: 10.1038/srep05031.

48. Zhang F.F. et al. Lycopene ameliorates neuropathic pain by upregulating spinal astrocytic connexin 43 expression. Life Sci. 2016 Jun 15;155:116-22. doi: 10.1016/j.lfs.2016.05.021. Epub 2016 May 16.

49. Kuhad A. et al. Lycopene attenuates thermal hyperalgesia in a diabetic mouse model of neuropathic pain. Eur J Pain. 2008 Jul;12(5):624-32. doi: 10.1016/j.ejpain.2007.10.008.

50. Gupta K.S. et al. Lycopene attenuates oxidative stress induced experimental cataract development: an in vitro and in vivo study. Nutrition. 2003 Sep;19(9):794-9. doi: 10.1016/s0899-9007(03)00140-0.

51. Schleicher M. et al. Diminishing Risk for Age-Related Macular Degeneration with Nutrition: A Current View. Nutrients. 2013 Jul; 5(7): 2405–2456. Published online 2013 Jul 2. doi: 10.3390/nu5072405

52. https://www.healthline.com/health/food-nutrition/maitake-mushroom#TOC_TITLE_HDR_1 

53. Zastrow M.L. et al. Designing hydrolytic zinc metalloenzymes. Biochemistry . 2014 Feb 18;53(6):957-78. doi: 10.1021/bi4016617.

54. Ananda S Prasad. Zinc in Human Health: Effect of Zinc on Immune Cells. Mol Med. 2008 May-Jun; 14(5-6): 353–357. doi: 10.2119/2008-00033.Prasad

55. Cai X.et al. Selenium Exposure and Cancer Risk: an Updated Meta-analysis and Meta-regression. Sci Rep. 2016; 6: 19213. doi: 10.1038/srep19213 

56. Flores-Mateo G. et al. Selenium and coronary heart disease: a meta-analysis. Am J Clin Nutr. 2006 Oct;84(4):762-73. doi: 10.1093/ajcn/84.4.762. 

57. González-Domínguez R. et al. Homeostasis of metals in the progression of Alzheimer's disease. Biometals. 2014 Jun;27(3):539-49. doi: 10.1007/s10534-014-9728-5.  

58. https://ods.od.nih.gov/factsheets/VitaminE-HealthProfessional/ 

59. Tantavisut S. et al. Effect of vitamin E on oxidative stress level in blood, synovial fluid, and synovial tissue in severe knee osteoarthritis: a randomized controlled study. BMC Musculoskelet Disord 18, 281 (2017). https://doi.org/10.1186/s12891-017-1637-7